Wednesday, April 24, 2013

Fear mongering and responsibilties - UK private vaccine clinic fuels MMR fears

Wales is currently heading the leader board, unfortunately not in a good way (like for rugby), but for measles infections in the Western hemisphere. Since February, Wales has had nearly 900 reported measles cases, 80 of them hospitalised, and, as feared, now the first suspected death, 25 year old Gareth Colfer-Williams. A lot has been written about responsibility. Obviously, Andrew Wakefield came up as the main culprit, who in turn blamed the government for the outbreak, which they rejected. To be honest, to solely blame Wakefield for the MMR mess would be too much credit to the man. The MMR mess is a media manufactuversy as beautifully summarised by Ben Goldacre. And the greed for the headlines has not stopped, and Wakefield is still given front page coverage by irresponsible papers.

Meanwhile, clinics providing single vaccines for measles and rubella are having a field day. Under the guise of "we are just responding to parental fears" one private provider of single measles vaccines, the Children's Immunisation Clinic (CIC), is advertising their services (£ 50/~US$ 75 registration plus £ 110/US$ 165) playing on the MMR-autism lie, while making totally untenable claims. This starts off with:
A high percentage of the children we vaccinate also have allergies and excema which indicate they may not have a perfectly functioning immune system – and even so we have no recorded adverse reactions.
Wow - that is impressive. I wonder how they do that, given that the Rouvax for example, one of the vaccines that CIC is offering, has the following adverse effects (my bold):
The most common side effects (in more than 1 in 10 subjects vaccinated) seen in clinical trials were irritability/agitation and rhinopharyngeal catarrh.
Other side effects that occurred in more than 1 in 100 subjects vaccinated in clinical trials were fever >38°C, injection site reaction, rash/cutaneous eruptions, conjunctivitis, nausea, vomiting, abdominal pain, diarrhea.
They then post a google link to Hannah Poling:
In October 2008 Hannah Poling an autistic child won a huge payout from a triple vaccine manufacturer, who said that she had a DNA genetic predisposition to become autistic given the MMR vaccine More Info…
 and concluding with this beauty:
In 2009 a Dr Walker in the USA has studied 275 autistic children and found in a large percentage of the cases that these children had the live Measles virus living in their gut after vaccination with the triple MMR .You can see more about this on the Daily Mail online. We do not use the same MMR or Measles virus vaccine in the vaccine we have chosen to use.
At this point already, I know I am never going to entrust my child to this clinic. The Daily Mail as a source for medical information? Honestly? The article they mean is the one previously bemoaned by Liz Ditz to have been posted without time stamp. Everything else is false, too.

Steven Walker's work was presented as a poster at the IMFAR conference in 2006, so no "study", not in 2009 either.

The abstract reports on results of 82 kids, 70 of them supposedly had measles vaccine virus in the gut. They tell us they have samples of >275, but have not analysed them all. Also, we know since Dr Bustin's testimony to the Autism Omnibus proceedings and Hornig et al that measles virus has not and cannot been found in the guts of > 80% of autistic children.

I think this claim "We do not use the same MMR or Measles virus vaccine in the vaccine we have chosen to use" is a lie. We already know that the clinic have not looked at Walker's data, since they misrepresent his findings. There is actually no way the people at the clinic can know what vaccines the children Walker looked at had received, because it is not reported in the abstract and a full paper has not been published since 2006. Given that Arthur Krigsman is the senior author of the abstract and children have been flown to him certainly at least from the UK, it is not clear which measles vaccine strain they had been vaccinated with. The French Rouvax, CIC are offering contains the Schwarz strain, which is also the measles strain used in GSK's Priorix, often used in Europe, the Indian Sii M-Vax, also on offer at CIC contains the Edmonston-Zagreb strain, also contained in the Swiss MMR-Triviraten (Berna) (CIC also import vaccines from China and Russia, if someone knows what vaccine strain is in those, email me).

Now, tell me how you can interpret the above facts and let the clinic appear in a good light. At best, their research was irresponsibly shoddy and they conveniently believed the Daily Mail. At worst, they are intentionally fuelling parental fears to sell their singles with false claims. It gets worse though - on the side bar, on the lower right, the clinic claim:




No Autism in over 10 years and amongst 18000 Patient Record Cards?! That is an outstanding record and it sounds dangerously like a "warranty" (I am not a lawyer, but a lawyer friend of mine pointed this out). Absolutely amazing, especially given that autism/ASD prevalence in the UK has been published to be 1 in 67, so they should be looking at about 282 patients on the spectrum, give or take a few. The reason for their "Clinic Highlight" might be their rather unorthodox method of assessment...  "We [the clinic] ask you [the patient] tell us if you have an adverse reaction within a few days of the vaccine."


They are obviously way out of their depth now, because it is all fine and well to make exaggerated claims when it is "only" about people's money. But now Wales is steering towards breaking the 1000 mark of measles cases (probably by next week), children and young adults are very very sick and one might have died, and the tolerance wears thin. While CIC is still keeping up appearances for the BBC, they seriously lost it in response to a short article in last week's Sunday Times and in the middle of a massive rant (which they really want you to read in its entirety and not quote out of context, so they mention it twice, probably because they know how tedious their rant is) about "offering singles will increase herd immunity" and "not politicising the issue" slip in this paragraph (all typos are [sic]):
9) CIC is not judgmental about parents’ choice of vaccine (any vaccination ,generally ,is better than none) nor does it have any preconceived ideas as to the causes, be they single trigger(s) or perhaps even several different combinations of triggers.
Anecdotally though,  that portion of the parents who tell us their stories , all confirm that there was a dramatic change in behaviour, either with their child ,from their circle of friends , neighbours or work colleagues; and these families make up a significant minority proportion  of our population,
The emotional and financial burden on the family, the limited funding of the UK’s Health sector all point to potential benefit of further timely research into those specific cases which may then be identifiable as being preventable An unencumbered choice for either single or multivalent MMR vaccine options would do less harm  than the current situation of a large portion not willing to engage in any vaccination programme.
Goodness, somebody save them from themselves. CIC are in a hole, they should stop digging. If they wanted to keep up the illusion that they are there "to help" instead of setting up shop in Swansea in the middle of an outbreak and charging full price for their services, maybe they should have offered their singles at cost? Just to maintain the illusion that they weren't hell bent on keeping the MMR autism lie alive for their own business interest? Just an idea.


Friday, April 19, 2013

Big CARma doesn't tell us about boosters

This day has been emotionally exhausting, especially for people in Wales and in the UK in general, so I thought I'd repost something that is not about measles from the brilliant Refutations to Anti-Vaccine Memes, this time taking on the "If your child is vaccinated, why are you worried about them catching anything from my child?" fallacy:

Love it: "when you purchase your first car seat, they don't tell you that boosters are required. Until they make a car sear that lasts a lifetime, I will never buy one". I can just imagine the indignant tone.
Cue someone who points out that car seats are "not injected into the blood stream".

First measles death feared in Wales - updated: man did have measles

Public Health Wales were warning that this would happen, now they are investigating the death of a 25 year old man as the first measles fatality in the current outbreak in South Wales, which hit 808 reported cases yesterday.

Updated (19/4/13 5pm): Public Health Wales have confirmed that the man who died in Swansea yesterday did indeed have measles.

Saturday, April 6, 2013

Welcome Necromancers - find the Wakefield threads here

I was wondering why we had a necromancer on an old thread linking directly to Andy Wakefield's site, that one callously disregarding anything but Wakefield's (business) interests. I discovered the potential explanation on page 25 of the Guardian magazine:

In his book Callous Disregard, Wakefield claims his findings of autistic enterocolitis have been "independently confirmed in five different countries". He cites five studies, two of which were authored by his friend, collaborator and Autism Team star Arthur Krigsman. One of those studies appeared in Autism Insights, a medical journal on whose board Krigsman sat in 2010. Two other studies were by Italian doctor Federico Balzola. According to the justthevax blog, the first of these was a case report of a single adult autistic patient with an inflamed bowel, and the second a "meeting abstract" that "never saw the light of day as a peer-reviewed study". The last one, a study by Dr Lenny Gonzalez, while not reporting finding a distinct "autistic enterocolitis", concludes that "autistic children have a high incidence of gastrointestinal disease". (my bold)
Ok, I admit, I am vain, and that section did generate a squee. The whole article is worth reading though, very well researched by Alex Hannaford, who is not shy to call Wakefield's operation what it is "Autism Inc.", a money generating machine. Hannaford tried to proffer Wakefield's (and Polly Tommey's) comments, but they only sent their lawyers' roboresponse (Wakefield did not fabricate data, there is such a thing as autistic enterocolitis, yada yada). Instead, he interviewed (among others) the lovely Autismum Martine O'Callaghan, founder of the cwtch-network, whose autistic son Cledwyn is just as lush as Michael Fitzpatrick's son James, and Ari Ne'eman, founder of the Autistic Self Advocacy Network. Not surprisingly, they emphasise the need to improve quality of life of autistic children and adults, by appropriate services (for example schools). Excellent article - read it.

Now for those who'd like to insist that really, Wakefield's works have been independently verified, please read my previous two blog posts:

"Independent" the Wakefield way (really something for the fail blog)

and

Still no independent confirmation of Wakefield's claims 

and feel free to add research you think we may have missed to discuss. Can I ask though that instead of just dropping a link into the comments, or basic copypasta from the usual anti-vaccine conspiracy sites, you leave one article at a time, with a proper, i.e. retrievable, citation and a blurb in your own words (much as we did in those blog posts) stating what was done in those papers and how this supports the "vaccines lead to gut damage leads to autism" notion? Cheers.


Monday, March 25, 2013

Deadline for the Australian Vaccine Network (AVN)

The inappropriately named "Australian Vaccine Network" or AVN for short was ordered by the NSW Fair Trading Commission to change its name to reflect its staunch anti-vaccine position rather than continue to mislead parents by 21 March 2013.
The future of the Australian Vaccination Network is in doubt, following the government rejection of five suggested new names for the group because they don't reflect its anti-vaccination stance.

The AVN has until March 21 to change its name or it faces deregistration, after NSW Fair Trading Minister Anthony Roberts issued a formal order that its name misleads the public.

The organisation does not present a balanced case for vaccination and has no medical evidence to back its anti-vaccination stance, he says.
The current AVN president, Greg Beattie proffered equally misleading name change suggestions that were rejected.
AVN president Greg Beattie told News Limited it was vital the words Australia and Vaccination remained in the group's name because they defined what the organisation was about.

He said the group had sent a letter to the Fair Trading Department to ask whether they would accept one of five suggested name changes.
These include Australian Vaccination Information Network and Australian Vaccination Choice.

"We can't just change our name under the Association's Incorporation Act, we must go through a process of consulting with our members and we need a 75 per cent majority vote," Mr Beattie said.
Mr. Beattie is able to keep "Australia" and "Vaccination" in their name and in fact can just add an "A" to the acronym to make it reflect what it really is, "Australian Anti-Vaccination Network".  This would be beneficial to them as typing in "AVN" will fetch you a porn site.

The AVN (the anti-vaxx one) has filed an appeal with the Administrative Decisions Tribunal and granted a stay until a hearing which has been set in June.
The AVN is fighting a December ruling by Fair Trading that it must change its name, and the warning was put in place on the condition that the group will not have to change its name until its challenge is heard in June.
However a condition has been set that the AVN must place a prominent warning on their website, blog and Facebook page by 26 March 2013 that directs consumers to the current order and misleading name.
Tribunal president, Judge O'Connor, responded to a bid by the AVN to stay proceedings on Friday by placing a number of conditions on the organisation.
A prominent consumer warning must be published on its websites and Facebook page by March 26.

It will state: "NSW Fair Trading has directed the AVN to change its name because it regards the name to be misleading.

"The AVN is challenging this direction and the challenge is currently before the NSW Administrative Decisions Tribunal."
We'll see what the AVN will do and keep you posted.

Update: Since it is 26 March 2013 in New South Wales, Australia, the AVN website and Facebook pages have been updated with the requisite warning.  Let's hope it serves to caution unsuspecting parents looking for factual vaccine information and irritate the AVN on a daily basis.


Wednesday, March 20, 2013

Don't panic at CDC's new autism numbers

The CDC has released the new autism numbers (Reuters, full report pdf) and the new prevalence is 1 in 50, or as Seth Mnookin tweeted earlier "1 child per school bus". My first thought, just like Matt Carey's over at LBRB, was that the removal of thimerosal seems not to have stopped the "autism epidemic". This seems to have escaped Dr "vested interest" Bob who is asking why nobody (but him, of course) is alarmed (especially not the CDC).

Meanwhile, the fabulous Emily Willingham, PhD explains the reasons behind the apparent increase. Read her post. Understand. Don't panic. As Emily says:
...if you look at the numbers and the report itself, you’ll see that overall, the numbers of people born with autism aren’t necessarily increasing dramatically. It’s just that we’re getting better and better at counting them. The next step is getting better at accepting autistic people, seeing their potential, and ensuring the supports and resources they need to fulfill that potential.
^ That.

Monday, March 18, 2013

COVRAC Guest blog: Influenza vaccination during pregnancy


We are very grateful to COVRAC, the author of today's guest post, who can be found over at his Facebook page "Chillin' Out, Vaxin', Relaxin' All Cool.
Seasonal influenza disease is dangerous to both a pregnant mother and the fetus. This is generally not in dispute, even by the most staunch antivaxers. But get about three Facebook comments into a discussion over flu shots for pregnant women (perhaps one that goes something like this, and invariably your self-proclaimed educated opponent with tell you in no uncertain terms that influenza vaccine has never been studied in pregnancy.
Well, then. Let's go over the numerous studies of influenza vaccines in pregnant women that have, it is claimed, never been done.

These studies have allegedly never been done on seasonal influenza vaccine in pregnant women. If they had been done, they would clearly demonstrate it to be safe.
http://www.ajog.org/article/S0002-9378(04)02102-7/abstract
http://www.ncbi.nlm.nih.gov/pubmed/20715555

These were apparently never done on the H1N1 vaccine. It would also have been clearly demonstrated to be safe (if they had been done).
http://www.ncbi.nlm.nih.gov/pubmed/20832495
http://www.ncbi.nlm.nih.gov/pubmed/21596080
http://idsa.confex.com/idsa/2010/webprogram/Paper3534.html
http://www.ajog.org/article/S0002-9378(11)00775-7/abstract

This study which obviously was never done showed far less premature births in mothers vaccinated during pregnancy.
http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000441;jsessionid=8B7B450C63F7196BE157DB7629B57432.ambra02

This other totally undone study looked specifically at miscarriages in women vaccinated in the first trimester, and did not find an increased risk.
http://idsa.confex.com/idsa/2011/webprogram/Paper30513.html

This one, which might look like a study showing decreased fetal deaths in the H1N1-vaccinated, is really just a bunch of fancy words meaning "404 page not found."
http://www.nejm.org/doi/full/10.1056/NEJMoa1207210

This study in the Canadia Medical Association Journal found that pregnancies during influenza season resulted in higher birth weight and less premature birth if the mother was vaccinated against influenza. But you can sooo tell it is CG and not real.
http://www.cmaj.ca/content/early/2012/02/21/cmaj.110754

These figments of your imagination show how influenza vaccination of pregnant mothers protects newborns from influenza.
http://archpedi.ama-assn.org/cgi/content/short/archpediatrics.2010.192
http://www.ncbi.nlm.nih.gov/pubmed/21058908
http://www.nejm.org/doi/full/10.1056/NEJMoa0708630

And finally, this indigestion-induced hallucination here from the American Journal of Obstetrics & Gynecology is a list of studies on the safety of influenza vaccine dating back to 1964. As Scrooge would say, "You may be an undigested bit of beef, a blot of mustard, a crumb of cheese, a fragment of an underdone potato."
http://www.influenza.org.nz/site_resources/Influenza/Influenza%202010/Safety_of_influenza_vaccination_during_pregnancy.pdf#page=2

Back to reality: These studies have, in fact, been done. An antivaxer will fall back to quoting a vaccine package insert, but it's evident that such a document does not reflect the entirety of the world's research on a given vaccine. Influenza vaccination in pregnancy has been studied in abundance. A flu shot is safe during pregnancy (without a known medical contraindication), does not cause miscarriage, and protects the health of pregnant women and their babies.