Toxin Gambit Part 3: Sucrose

Just the Vax is doing a series on vaccine excipients with the hope that we can get through all of them to provide clear and reasoned information about how they are not toxic along with defining what a toxin is.  We have Toxin Gambit Part 1: Formaldehyde, Toxin Gambit Part 2: Polysorbate 80 ( with bonus material that includes how anti-vaxxers are innumerate) and now our latest instalment is about sucrose.  Some of you may stop laughing now. 

This post is actually a re-post of Sucrose: Dangerous Poison or Plain Table Sugar? which has been written by Reuben of The Poxes Blog.  We hope you find this informative and puts a little perspective on what is really a toxin.

Sucrose: Dangerous Poison or Plain Table Sugar?

The answer is clearly "plain table sugar". I'll explain why in a little bit. But let me first show you an anti-vaccine rant about sucrose (emphases mine):

"Here is the promised Sucrose information. It can also be found in the notes section.
Sucrose:Material Safety Data Sheet:http://www.sciencelab.com/msds.php?msdsId=9927285 

The first thing I want to point out is that the MSDS is for the safe handling of large quantities of the chemical. It would be seen in a binder on the floor of a manufacturing plant, storage facility and anywhere it may come in contact with humans working with it. As we can see, this MSDS was updated on 6/09/2012 at 12:00pm. This is important information to note. One must always be sure the MSDS you find is up to date. 

I am NOT going to break down each section of the MSDS. However, I am going to point out Section 3 and 4. As we can see it has a listing of acute and chronic health effects and the first aid required for acute exposure.

The acute affects make it dangerous for skin and eyes to come in contact with it, as well as an indication that ingestion would be unwise. Treating acute exposure is covered in Section 4 of the MSDS. The chronic affects would be difficult to pin down to exclusive exposure to this chemical. We do see it has carcinogenic effects label of A4.

Here are 2 websites that break down the classes of carcinogenicity:

http://sis.nlm.nih.gov/enviro/iupacglossary/annex3.html

http://www.hc-sc.gc.ca/ewh-semt/occup-travail/whmis-simdut/carcinogenesis-carcinogenese-eng.php

It is important to note that “Not classifiable as a human carcinogen” often means the government has not conducted definitive studies to rule one way or the other. Although we are seeing many independent university studies regarding this specific chemical.

All one has to do is Google “dangers of sucrose” and you will be bombarded with many health sites, such as livestrong.com, telling of the danger this artificial sweetener poses. I want to present studies though. There have been none in recent years to determine whether long term exposure to sucrose would cause permanent damage to the human body. At least none that I could find.

(Please, if you have links to the study summary in PubMed, post them!)

Here is what I did find:http://www.ncbi.nlm.nih.gov/pubmed/9519848 - This relates to a study done with rats and dogs, but it was a short study. Because I am not a chemist nor a biologist, I’m not sure how this translates to humans consumption. This is an older study and I could find nothing newer.

One more, and it is from 1998. It shows no long term affects:http://www.ncbi.nlm.nih.gov/pubmed/9519849I am not going to report things that don’t exist. However, the MSDS shows definite hazards to being exposed to the chemical in the event of a spill. Again, if you have links to the specific studies I keep seeing mentioned, post them or message them so I can update the notes section and my own records.

Carrie 

**Later today I will address the next 3 ingredients and post it to notes and the wall. Thank you."

Of course she's not a chemist or biologist. If she was, she would know what sucrose is.

There are these chemicals called sugars. They consist of carbons attached to hydrogen and oxygen. If they have six carbons, they are "hexoses". "Hex" is the prefix for "six". If they have five carbons, they are "pentoses", with "pent" being the prefix for five. Human beings take in these hexoses and pentoses and break them down via chemical reactions. These chemical reactions produce energy. Our cells then use that energy to grow and multiply, repair themselves, and just, you know, live.

You are warm right now because you are actively breaking down these sugars and the reactions produce heat.

You've probably heard of "glucose". It's the sugar in your blood right now. It's a hexose, and it packs quite a punch when it comes to energy. The energy is stored in the bonds between the carbons. Break those bonds, and you release a ton of energy.

You've probably also heard of "fructose". It is the sugar in plants. We have glucose, and plants have fructose. We consume fructose when we eat fruits and vegetables. Some have more fructose than others. "High fructose corn syrup" is a corn product (corn has fructose) that has been refined to contain the most fructose possible. It's super sweet because it has a lot of sugar in it. Fructose, a pentose hexose, is a sugar.

Still with me?

Here is a picture of glucose:

Note the six carbons are labeled 1-6.

Now, here is a picture of fructose:

They're not labeled, but there are five six carbons there.

Now, let's talk sucrose.

The reason why that anti-vaccine person is demonizing sucrose is because it is contained in some vaccines. If it is in a vaccine, then either the devil defecated it or aliens produced it. That is to say that anti-vaccine people think that everything inside a vaccine vial is absolute evil and/or not of this world.

But here is why the government has never tested sucrose for toxicity. Check out the picture of sucrose:

Look familiar?

That's right, dear reader! Sucrose is glucose put together with fructose. It's also known as table sugar. It's the white powder that you use to sweeten your coffee or your muffins. Pineapples and apricots produce sucrose as the main sugar. When you eat sucrose, an enzyme in your gut breaks it apart into glucose and fructose. Then these are absorbed into the bloodstream and metabolized.

When you are injected with sucrose, or you are given it by IV as part of a medical therapy, a similar enzyme breaks it apart in your circulation. Then your metabolism takes over.

"But wait, she said it could be a carcinogen?" Tumors (large groups of cancer cells) also need energy. They're cells! So a well-fed person who eats plenty of refined sugar and has cancer is only feeding those cells. It's not a cancer-cause as much as it is a cancer-collaborator.

So don't fear sucrose. It's not evil. It's delicious.

Then again, fear it a little bit if you're overweight or a diabetic... Or both.

PS: Would you like the government to spend millions of dollars and thousands of man-hours to study table sugar?

The Toxin Gambit Part 1: Formaldehyde

We will be conducting a multiple-part series describing some of the vaccine constituents that many consider 'toxins' or just have what the actual chemical is, just plain wrong. The first part of our series will be dedicated to information regarding formaldehyde, what it is, why it is in vaccines and any health implications. So thank you to Valo for your suggestion.

For the purpose of this series, it is important to understand the metric scale, not so much the actual measurements but their relationship to one another. For example, if a microgram (mcg) is a grain of sand, then a milligram (mg) is a slice of American cheese, so a gram (g) is an average 5.5 year-old boy and a kilogram (kg) would be 7 H2 Hummers. Again, these aren't actual weights, volumes or measurements, but rather, their differences on a visual scale.

Formaldehyde is a naturally-occurring chemical that can also be synthesised. The chemical formula is CH2O and is also known as methanal (not to be confused with methanol), formal and methyl aldehyde. It is also not to be confused with formalin, which is an aqueous solution of formaldehyde. Numerous isomers of formaldehyde exist but they are not formaldehyde. It is used in the manufacture of resins that are then used for the production of pressed wood products, paper, textile fibres, adhesives and plastics (EPA 2009 and WHO 2006). Of course, those involved with the manufacturing of products with formaldehyde may sustain occupational exposure and subsequent pathologies (EPA, 2009 and WHO, 2006). Formaldehyde is also a by-product of tobacco smoke and combustion reactions from stoves, kerosene space heaters and automobiles (EPA 2009).

Naturally occurring sources of formaldehyde are found in plants, fruits, vegetables, animals (including humans) and seafood (Mason et al. 2004 and Inchem 1989). Table 14 of the Environmental Health Programme on Chemical Safety: Formaldehyde, and Table 95.2, Chapter 95: Formaldehyde, lists some commonly-consumed foods and their formaldehyde concentrations. (Clary and Sullivan 2001 and Inchem 1989). In a study of Shiitake mushrooms, investigators reported formaldehyde concentrations of 100-300 mg/kg; this wide variation is a result of a combination of analysis techniques, naturally-occurring formaldehyde and also possible contamination with exogenous formaldehyde (Mason et al. 2004).

Formaldehyde is a normal, essential human metabolite with a biological half-life of about 1.5 minutes (Clary and Sullivan 2001). It is endogenously produced and is involved with methylation reactions for and biosynthesis of some proteins and nucleic acids. It is also rapidly metabolised to formate and excreted in urine or to carbon dioxide and exhaled (WHO, 2006 and Clary and Sullivan 2001). Some common routes of exposure for exogenous formaldehyde include dermal, from occupational handling, inhalation, from occupational exposure and environment, oral via dietary intake and of course, intramuscularly or subcutaneously from vaccines. (Franks 2005, Clary and Sullivan 2001 and Inchem 1989).

Human normal blood concentrations of formaldehyde are 2.74 +/- 0.14 mg/L (Franks 2005). The average adult male (86 kg) in the U.S. has a blood volume of 5.8 litres; the average adult female (74 kg) has a blood volume of 5.0 litres and an average 2 month old infant (5 kg), 0.43 litres. So this translates to 15.1-16.7 mg of normal formaldehyde range in an adult male, 13.0-14.4 mg in an adult female and 1.1-1.2 mg in a 2 month-old infant which works out to be 0.22-0.24 mg/kg (CHOP 2008 and Franks 2005). Using the visual scale provided earlier for the infant, that would be a little more than 1 slice of American cheese/35 H2 Hummers.

Toxic levels of formaldehyde can induce a variety of illness from localised skin/respiratory tract irritation to cancer (Bosetti et al. 2008, Sundstrom et al. 2001 and Pandley et al. 2000). Inhalation of 1.0-2.0 parts per million or ppm (ppm=mg/kg) is considered mildly irritating, while 3.0 ppm causes moderate eye irritation although there is variation of sensitivity in individuals (Sundstrom et al. 2001 and Inchem 1989). Chronic inhalation studies on rats and mice have resulted in nasal cavity squamous cell carcinomas, when exposed to levels above 6-15 ppm (Bosetti et al. 2008 and Clary and Sullivan 2001). Formaldehyde toxicity resulting in death occurs in humans at a volume of about 60-90ml (Pandey 2000). The CDC conducted a survey of 'travel trailers' used for displaced people from hurricanes Katrina and Rita and found levels ranging from 0.003-0.59 ppm with an average of 0.077 ppm (CDC 2008). Thus far, only symptoms of local irritation have been reported (CDC 2008). A 2005 study of single-family homes in 3 cities detected an average of 0.17 ppm and 0.016-0.025 ppm in travel trailers (Weisel et al. 2005).

Formaldehyde in vaccines is left over from the production process, where it serves a couple of different functions, depending upon the type of antigens used. Essentially, it is used for killing cells and/or inactivating toxins. For example, the diphtheria-tetanus-acellular pertussis vaccine is a toxoid vaccine. The toxins produced by the bacteria are what causes illness in humans and what we need antibodies against. The addition of formaldehyde internally cross-links the toxin and also cross-links it to other toxins, effectively detoxifying to eliminate pathogenicity. Viral vaccines such as influenza and hepatitis A vaccines utilise formaldehyde to inactivate viral activity, allowing the recipient to produce antibodies to the antigens without pathogenicity (Aunins et al. 2000).

The actual amount in vaccines is minuscule, even when considering an infant that receives the full CDC schedule. If you look at this table, it contains a list of vaccines and their final formaldehyde content. Not included in this table is Pentacel which contains 0.005mg of formaldehyde. If all vaccines are given as per the CDC recommendation and separately, the most a 2 month old infant would receive is 0.1204 mg of formaldehyde or 120.4 mcg. Going back to what normal formaldehyde levels for a 5kg, 2-month old infant are 1.1-1.2 mg or 0.22-0.24mg/kg so the total formaldehyde exposure from vaccines would raise that to 1.22-1.32 mg or raises the baseline level by less than 1 grain of sand/35 Hummers. Put another way, the amount contained within a vaccine is more than 50 times less than what is in a pear.

Given what is known about human formaldehyde metabolism, excretion and toxic levels, along with what is actually in vaccines, we hope that this gives some perspective about the safety of the amount of formaldehyde that an infant would receive via vaccines. There is simply no valid argument, beyond the scope of fear-mongering that formaldehyde exposure from vaccines is implicated in any health problems, whatsoever.

References:
Aunins JG, Lee AL, Volkin DB. Vaccine Production. In: Bronzino JD, ed. The Biomedical Engineering Handbook 2nd ed. Vol. 2. New York, NY: Springer Publishing; 2000. http://books.google.com/books?id=T2UIoAxcFdIC&pg=PT175&lpg=PT175&dq=&source=bl&ots=J4Skfly-bt&sig=InDm5MbbsfSOztSu5WoeSGAYh7A&hl=en&ei=s938SciZD4TCM6Gi8csE&sa=X&oi=book_result&ct=result&resnum=8. Accessed May 10, 2009:105-8—105-9.

Bosetti C, McLaughlin JK, Tarone RE, Pira E, La Vecchia C. Formaldehyde and cancer risk: a quantitative review of cohort studies through 2006 . Annals of Oncology. 2008; 19:29-43. http://annonc.oxfordjournals.org/cgi/reprint/19/1/29.pdf. Accessed May 10, 2009.

The Children's Hospital of Philadelphia (CHOP). Vaccine Education Center Web site. http://www.chop.edu/consumer/jsp/division/generic.jsp?id=75809. Accessed May 10, 2009.

Clary JJ and Sullivan, Jr. JB. Formaldehyde. In: Sullivan, Jr. JB and Krieger GR, eds. Clinical Environmental and Toxic Exposures. 2nd ed. Philadelphia, PA: Lippincott, Williams and Wilkins; 2001. http://books.google.com/books?id=PyUSgdZUGr4C&pg=PA1008&lpg=PA1008&dq=formaldehyde+human+normal+metabolite&source=bl&ots=IJTP64uYmW&sig=jttT7L4_AseC6hm3eVXzUP56hQI&hl=en&ei=Gmv7SfTkJ46UMrvr3dQE&sa=X&oi=book_result&ct=result&resnum=1#PPP1,M1. Accessed May 10, 2009:1007-1008 and 1010.

Indoor Air Quality. U.S. Environmental Protection Agency (EPA) Web site. http://www.epa.gov/iaq/formaldehyde.html. Accessed and link repaired Aug 1, 2012.

Franks SJ. A mathematical model for the absorption and metabolism of formaldehyde vapour by humans [abstract]. Toxicology and Applied Pharmacology. 2004; 206(3):309-320. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXH-4F7B42G-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7617394a3010f1b021e3164141aefec1. Accessed May 10, 2009.

Environmental Health Criteria 89: Formaldehyde. International Programme on Chemical Safety (INCHEM) Web site. http://www.inchem.org/documents/ehc/ehc/ehc89.htm#SubSectionNumber:5.1.4. Accessed May 10, 2009.

Mason DJ, Sykes MD, Panton SW, Rippon EH. Determination of naturally-occurring formaldehyde in raw and cooked Shiitake mushrooms by spectrophotometry and liquid chromatography-mass spectrometry [abstract]. Food Additives and Contaminants. 2004; Nov;21(11):1071-1082. http://www.informaworld.com/smpp/content%7Edb=all?content=10.1080/02652030400013326. Accessed May 10, 2009.

Pandey CK, Agarwal A, Baronia A, Singh N. Toxicity of ingested formalin and its management [Abstract]. Human & Experimental Toxicology. 2000;Jun,19(6);360-366. http://www.ncbi.nlm.nih.gov/pubmed/10962510?ordinalpos=&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.SmartSearch&log$=citationsensor. Accessed May 10, 2009. PMID: 10962510.

CDC Final Report on Formaldehyde Levels in FEMA-Supplied Travel Trailers, Park Models, and Mobile Homes Web site http://www.cdc.gov/nceh/ehhe/trailerstudy/pdfs/FEMAFinalReport.pdf. July 2, 2008. Accessed May 10, 2009.

Weisel CP et al. Relationships of indoor, outdoor, and personal air (RIOPA). Part I. Collection methods and descriptive analyses [abstract]. Research Report (Health Effects Institute). 2005;Nov(130 Pt 1):1-107; discussion 109-127. http://www.ncbi.nlm.nih.gov/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=16454009&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVCitation. Accessed May 10, 2009. PMID: 16454009.

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. World Health Organization (WHO). Volume 88 Formaldehyde, 2-Butoxyethanol and 1-tert-Butxypropan-2-ol. 2006. Web site. http://monographs.iarc.fr/ENG/Monographs/vol88/volume88.pdf. Accessed May 10, 2009.